In the country of Gazth-Sonika, civil war rages on. There, a mercenary called Madlax plies her trade, with almost supernatural skill. In the seemingly peaceful country of Nafrece, Margaret Burton lives a tranguil life. As separate as their lives may seem, the two are connected by ties of mystery and by a holy book that is also sought by the shadowy organisation Anfan. As Margaret and Madlax follow the path of their destiny they come ever closer to uncovering the truth, with no guarantee that it is a truth they can bear to learn.