In the year of the lord 1928 AD, in a city of Brooklyn very different from our own, the prosperity of the decade has also summoned an evil that can not be fought with normal weapons. The Magdalan Order has evolved to specialize in exorcisms of poltergeists and demonic apparitions, through whatever means required, including, (but not limited to) the use of holy water and fully automatic weapons firing blessed silver rounds. The young Christian warrior-priestess, Rosette Christopher and her assistant, the daemon Chrno are ready to take on any evil opponent, not matter what kind of damage and destruction they cause, all in the name of the holy order.
In addition Rosette\'s life is dependent on Chrno, as they made a vow that shortens Rosette\'s life each time Chrno shows his true demonic form to help his partner finding her lost brother Jonathan, who seems to have switched to evil 7 years ago.