Brother, Dear Brother is a series about a failed lesbian romance. From what I hear it is a very good series. It is currently on fan sub through techno girls.
F3, I believe it's incest last time I checked, but they're both girls. I'd check out Cool Devices like suggested, it's not all bondage, episodes like Sacred Girl have lesbian interactions, but it also turned into a threesome. If she's grossed out by incest anime, avoid anything I've mentioned.
Nah it doesn't bother me (yaoi is something completely different). I'll check out some of those titles.